Description

Lorazepam-13C2,15N is a stable isotope-labeled analog of the widely prescribed benzodiazepine, Lorazepam, specifically enriched with carbon-13 and nitrogen-15 isotopes. This compound is essential as a certified reference material and an internal standard for the precise quantification of Lorazepam in complex biological matrices using advanced analytical techniques. It is a critical tool for pharmaceutical research, forensic toxicology, and clinical laboratories engaged in method development, validation, and quality control. The product is identified by CAS NO 907200-04-8.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of Lorazepam in plasma, serum, and urine for pharmacokinetic and therapeutic drug monitoring studies.
• Pharmaceutical R&D: Used in drug metabolism and disposition (DMPK) studies to track the parent drug and potential metabolites, aiding in the development of new benzodiazepine-based therapeutics.
• Forensic and Clinical Toxicology: Enables precise identification and quantification in post-mortem analyses and cases of drug-facilitated crimes, ensuring reliable and legally defensible results.
• Reference Standard Manufacturing: Acts as a primary standard for the calibration of analytical instruments and the certification of commercial Lorazepam reference materials.
• Method Development & Validation: Critical for developing highly specific and sensitive analytical methods, compensating for matrix effects and instrument variability.
• Regulatory Compliance Testing: Supports compliance with FDA, EMA, and other global regulatory guidelines for bioanalytical method validation in support of drug submissions.

Basic Information

Product Name	Lorazepam-13C2,15N
CAS No.	907200-04-8
Molecular Formula	C15H10Cl2N2O2 (with 13C2, 15N labeling)
Molecular Weight	~325.1 (labeled)
Synonyms	7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1,4-benzodiazepin-2-one-13C2,15N; 13C2,15N-Lorazepam; Lorazepam Isotopically Labeled; Ativan-13C2,15N (labeled variant); Temesta-13C2,15N (labeled variant); 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one-13C2,15N; Lorazepam Internal Standard; Lorazepam-d0 (13C2,15N)
EINECS	Contact for details

Quality Control

Every batch of Lorazepam-13C2,15N is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for critical analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Comprehensive Certificates of Analysis (COA) are provided, detailing parameters such as isotopic enrichment, chemical purity, and identity confirmation via orthogonal techniques. We support compliance with cGMP and ISO 17034 for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Enrichment	≥99 atom % 13C; ≥99 atom % 15N
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.