Description

Necitumumab CAS NO 906805-06-9 is a recombinant human IgG1 monoclonal antibody designed to specifically bind to the epidermal growth factor receptor (EGFR). This targeted therapeutic agent is of significant importance in oncology for its role in inhibiting tumor cell proliferation and survival. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced cancer treatments.

Application

• Primary Therapeutic Use: As a key active pharmaceutical ingredient (API) in combination therapy for the treatment of metastatic squamous non-small cell lung cancer (NSCLC).
• Oncology Research: Used in preclinical and clinical research to study EGFR inhibition mechanisms and combination treatment regimens.
• Biopharmaceutical Development: Serves as a reference standard or material in the development and validation of biosimilar products.
• Process Development: Employed in the optimization of upstream cell culture and downstream purification processes for monoclonal antibody manufacturing.
• Quality Control & Analytical Testing: Utilized as a standard in assays for potency, purity, and identity testing of related biologic products.

Basic Information

Product Name	Necitumumab
CAS No.	906805-06-9
Molecular Formula	C6484H10042N1732O2020S44
Molecular Weight	Approx. 146 kDa
Synonyms	IMC-11F8; LY3012211; Anti-EGFR Recombinant Monoclonal Antibody; Human Anti-EGFR IgG1 kappa; Necitumumab (USAN/INN); Recombinant Human IgG1 Anti-EGFR mAb; EGF Receptor Inhibitor IMC-11F8
EINECS	Contact for details

Quality Control

Our Necitumumab is manufactured under strict quality systems. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and safety, meeting stringent specifications for biopharmaceutical actives. Certificates of Analysis (COA) detailing results for purity (by SEC-HPLC and CE-SDS), potency (cell-based bioassay), endotoxin levels, and sterility are provided.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -70°C. Avoid repeated freeze-thaw cycles. Under these conditions, the product remains stable for the duration indicated on the certificate of analysis. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (Mass Spec)	Conforms
Purity (SEC-HPLC)	≥ 98.0% Monomer
Purity (CE-SDS, Reduced)	≥ 95.0% Heavy and Light Chain
Potency (Cell-Based Assay)	90.0% - 110.0% of Reference Standard
Protein Content (A280)	90.0% - 110.0% of Label Claim
Endotoxin	< 1.0 EU/mg
Sterility	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.