Description

n-(Trifluoroacetyl)-L-Thyroxine Methyl Ester is a key synthetic derivative of the thyroid hormone thyroxine (T4), modified with a trifluoroacetyl protecting group and a methyl ester. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis and analytical study of thyroid hormone analogs and potential therapeutic agents. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling the exploration of hormone metabolism, receptor binding, and the development of novel diagnostic tools.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthetic pathway for novel thyroid hormone receptor agonists, antagonists, and prodrugs.
• Analytical Reference Standard: Used in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for the quantification and qualification of thyroxine and its metabolites in biological samples.
• Biochemical Research: Employed in studies investigating thyroid hormone action, metabolism, and transport mechanisms at the molecular level.
• Proteomics & Labeling Reagent: The trifluoroacetyl group can be utilized in chemical proteomics for selective labeling or as a handle for further bioconjugation in probe development.
• Metabolite Synthesis: Facilitates the synthesis of specific thyroxine metabolites for toxicological and pharmacokinetic studies.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Thyroxine Methyl Ester
CAS No.	906325-95-9
Molecular Formula	C18H14F3I4NO5
Molecular Weight	906.91 g/mol
Synonyms	L-Thyroxine, O-(2,2,2-trifluoroacetyl)-, methyl ester; Methyl 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylalaninate 2,2,2-trifluoroacetate; T4 Methyl Ester Trifluoroacetate; Thyroxine Methyl Ester Trifluoroacetamide Derivative; N-Trifluoroacetylthyroxine Methyl Ester; 3,3',5,5'-Tetraiodo-L-thyronine Methyl Ester N-Trifluoroacetate
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Thyroxine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.