Description

4-Bromo-3-Hydroxymethyl-Benzonitrile is a versatile aromatic nitrile derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromine substituent and a hydroxymethyl group on the benzonitrile core, makes it a valuable intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators, leveraging its halogen and functional group diversity.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts due to its modifiable functional handles.
• Material Science Research: Intermediate for creating monomers and functionalized polymers with specific electronic or optical properties.
• Chemical Biology Probes: Serves as a starting point for synthesizing fluorescent tags or bioactive probes for target identification and validation.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	4-Bromo-3-Hydroxymethyl-Benzonitrile
CAS No.	905710-66-9
Molecular Formula	C8H6BrNO
Molecular Weight	212.04 g/mol
Synonyms	3-(Hydroxymethyl)-4-bromobenzonitrile; 4-Bromo-3-(hydroxymethyl)benzonitrile; Benzonitrile, 4-bromo-3-(hydroxymethyl)-; 905710-66-9; 4-Bromo-3-hydroxymethylbenzonitrile; 4-Bromo-3-(hydroxymethyl)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Hydroxymethyl-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.