Description

Ganitumab CAS NO 905703-97-1 is a fully human monoclonal antibody designed to specifically target and inhibit the type 1 insulin-like growth factor receptor (IGF-1R). This targeted mechanism is of significant interest in oncology research for its potential to disrupt critical tumor growth and survival pathways. It is primarily utilized by pharmaceutical companies and research institutions engaged in the development of novel cancer therapeutics and advanced biomedical studies.

Application

• Oncology Research & Drug Development: A key investigational agent for studying IGF-1R signaling in various cancer models, including breast, pancreatic, and colorectal cancers.
• Preclinical Studies: Used in in vitro and in vivo experiments to validate the IGF-1R as a therapeutic target and assess antitumor efficacy.
• Biomarker Research: Employed in assays to understand patient stratification and potential predictive biomarkers for IGF-1R-targeted therapies.
• Combination Therapy Investigations: Studied in conjunction with chemotherapy, radiation, or other targeted agents to evaluate synergistic effects.
• Reference Standard: Serves as a critical biological reference material in analytical method development and quality control for biosimilar or novel antibody programs.
• Diagnostic Tool Development: Can be used in the development of companion diagnostic tests to identify tumors with IGF-1R dependence.

Basic Information

Item	Details
Product Name	Ganitumab
CAS No.	905703-97-1
Molecular Formula	Contact for details
Molecular Weight	Approx. 145 kDa
Synonyms	AMG 479; Anti-IGF-1R Monoclonal Antibody (AMG 479); IGF-1R Inhibitor AMG 479; Fully Human Anti-IGF1R IgG1 Monoclonal Antibody; Ganitumab (AMG 479); IGF1R Monoclonal Antibody
EINECS	Contact for details

Quality Control

Our Ganitumab is manufactured and controlled under a stringent quality management system. Each batch is subjected to a comprehensive panel of analytical tests, including but not limited to identity confirmation, purity assessment by SEC-HPLC, determination of biological activity, and testing for endotoxins and host cell proteins. A Certificate of Analysis (COA) documenting full compliance with release specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive) and should be handled under controlled conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (SEC-HPLC / MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Content (A280)	90% - 110% of label claim
Biological Activity (Cell-Based Assay)	Meets established potency range
Endotoxin	< 1.0 EU/mg
pH	6.0 - 7.5 (for solution)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.