Description

Fostamatinib is a potent and selective oral spleen tyrosine kinase (SYK) inhibitor, a key target in immunoreceptor signaling. Its primary value lies in its therapeutic application for treating chronic immune thrombocytopenia (ITP) and other autoimmune and inflammatory conditions. This active pharmaceutical ingredient (API) is critical for pharmaceutical manufacturers and research institutions developing targeted therapies for hematologic and inflammatory diseases.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of oral tablets for the treatment of chronic immune thrombocytopenia (ITP) in adult patients.
• Oncology Research: Investigated in preclinical and clinical studies for potential applications in various B-cell malignancies and lymphomas where SYK signaling is implicated.
• Autoimmune Disease Research: Used as a research tool to study SYK inhibition in models of rheumatoid arthritis, lupus, and other autoimmune disorders.
• Reference Standard: Serves as a high-purity chemical reference standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Process Chemistry & Development: Employed in the scale-up and optimization of synthetic routes for fostamatinib production within API manufacturing facilities.

Basic Information

Product Name	Fostamatinib
CAS No.	901119-35-5
Molecular Formula	C₂₉H₂₇FN₆O₉
Molecular Weight	622.56 g/mol
Synonyms	R788; Fostamatinib Disodium; (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2,3-dihydrobenzo[b][1,4]dioxin-3-yl)methyl dihydrogen phosphate; R935788; Tamatinib Fosdium; R 788
EINECS	Contact for details

Quality Control

Our Fostamatinib is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters is provided with every shipment to support regulatory compliance for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.