Description

Anatibant CAS NO 209733-45-9 is a high-purity, non-peptide bradykinin B2 receptor antagonist of significant interest in pharmaceutical research and development. This compound is valued for its potent and selective inhibition of the bradykinin pathway, a key mediator in inflammatory and pain responses. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics for conditions such as hereditary angioedema, neuropathic pain, and inflammatory diseases.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical studies for novel drug candidates targeting the bradykinin B2 receptor.
• Inflammation & Pain Research: Used as a pharmacological tool to investigate the role of bradykinin in inflammatory pathways, neuropathic pain models, and vascular permeability.
• Hereditary Angioedema (HAE) Therapeutics: Investigated for the development of next-generation prophylactic and acute treatments for HAE by blocking the bradykinin-mediated swelling.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to identify and characterize new B2 receptor antagonists.
• Academic & Clinical Studies: Supports fundamental research in physiology and pharmacology to understand bradykinin's role in various disease states.

Basic Information

Product Name	Anatibant
CAS No.	209733-45-9
Molecular Formula	C₂₀H₂₈N₄O₄
Molecular Weight	388.46 g/mol
Synonyms	Anatibant; FR 173657; (R)-2-[[(3R)-3-(1,3-Benzodioxol-5-yl)-3-[[(6-methoxy-2-naphthalenyl)sulfonyl]amino]propanoyl]amino]-3-(1H-imidazol-4-yl)propanoic acid; Bradykinin B2 Receptor Antagonist FR-173657; FR173657
EINECS	Contact for details

Quality Control

Our Anatibant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by HPLC. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.