Description

Desidustat is a potent and selective small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH). This compound is of significant interest for its role in stimulating endogenous erythropoietin production, offering a novel therapeutic approach for treating anemia associated with chronic kidney disease. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for drug development and clinical studies. Desidustat CAS NO 1616690-16-4 represents a key intermediate in the development of next-generation treatments for renal anemia.

Application

• Pharmaceutical Research & Development: As a reference standard and key intermediate in the synthesis of novel HIF-PH inhibitor drug candidates.
• Preclinical & Clinical Studies: Used in pharmacological, pharmacokinetic, and toxicological studies to evaluate efficacy and safety profiles.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a critical building block in the scaled-up production of the final drug substance.
• Mechanistic Biology Studies: A vital tool for researchers investigating cellular oxygen-sensing pathways, HIF stabilization, and erythropoiesis.
• Analytical Method Development: Employed as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	Desidustat
CAS No.	1616690-16-4
Molecular Formula	C₁₉H₁₇N₅O₄
Molecular Weight	379.37 g/mol
Synonyms	Desidustat; 2-(1-Hydroxy-4-methoxy-7-phenoxyisoquinoline-3-carbonyl)hydrazine-1-carboximidamide; ZYAN1; ZYAN 1; GSK1278863 analog; HIF-PH Inhibitor ZYAN1; (1-Hydroxy-4-methoxy-7-phenoxyisoquinoline-3-carbonyl)guanidine; 1-Hydroxy-4-methoxy-7-phenoxy-3-isoquinolinecarboxylic acid carbohydrazonamide
EINECS	Contact for details

Quality Control

Our Desidustat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.