Description

Voxelotor CAS NO 1446321-46-5 is a small molecule, allosteric hemoglobin S polymerization inhibitor used as a therapeutic agent. This compound matters as it represents a significant advancement in the treatment of sickle cell disease by directly targeting the root cause of red blood cell sickling. Pharmaceutical manufacturers and research institutions developing treatments for hemoglobinopathies require this high-purity active pharmaceutical ingredient (API).

Application

• Active Pharmaceutical Ingredient (API) in the formulation of sickle cell disease therapeutics.
• Pharmaceutical Intermediates for the synthesis of related drug candidates and analogs.
• Biochemical Research for studying hemoglobin-oxygen affinity modulation and sickling mechanisms.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Pre-clinical and Clinical Development for new drug applications and regulatory submissions.

Basic Information

Product Name	Voxelotor
CAS No.	1446321-46-5
Molecular Formula	C19H16N2O5
Molecular Weight	352.34 g/mol
Synonyms	Voxelotor; GBT440; 2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde; Oxbryta (Brand Name); (E)-2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde; GBT-440; Benzaldehyde, 2-hydroxy-6-[[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy]-
EINECS	Contact for details

Quality Control

Our Voxelotor is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical use. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications aligned with ICH guidelines. We support our partners through all stages of development with regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.