Description

1,1′-Bis{(R)-{(Rp)-2-[(S)-1-(Dimethylamino)Ethyl]Ferrocenyl}Phenylphosphino}Ferrocene is a sophisticated, chiral ferrocenyl phosphine ligand of significant importance in asymmetric catalysis. Its complex, well-defined stereochemistry makes it a powerful tool for inducing high enantioselectivity in transition metal-catalyzed reactions. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and fine chemical industries for the development of chiral active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, critical for producing single-enantiomer pharmaceutical compounds.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and other C-C bond-forming processes to create chiral centers with high fidelity.
• Pharmaceutical Intermediate Synthesis: Key component in the catalytic synthesis of chiral building blocks for complex drug molecules, including antibiotics, antivirals, and cardiovascular agents.
• Fine Chemical and Agrochemical Production: Used to manufacture enantiomerically pure flavors, fragrances, and advanced crop protection agents.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis research within university and corporate laboratories.
• Catalyst Screening Libraries: Included in high-throughput screening kits for discovering new asymmetric transformations and optimizing reaction conditions.

Basic Information

Product Name	1,1′-Bis{(R)-{(Rp)-2-[(S)-1-(Dimethylamino)Ethyl]Ferrocenyl}Phenylphosphino}Ferrocene
CAS No.	900505-82-0
Molecular Formula	C58H60Fe2N2P2
Molecular Weight	942.71 g/mol
Synonyms	(R,R)-1,1′-Bis[(S)-1-(Dimethylamino)ethyl]-2,2′-bis(diphenylphosphino)ferrocene; Josiphos SL-J009-1; (R)-(S)-Josiphos; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine (common misassignment); Chiral Ferrocenyl Diphosphine Ligand; Walphos analogue; Ferrocene-based Josiphos ligand; (R,R)-DIPAMP-Fc derivative
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and controlled under strict quality management to ensure exceptional purity and stereochemical integrity, which are paramount for catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity, and identity confirmation. Our production adheres to cGMP guidelines where applicable, ensuring traceability and consistency for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and decomposition. For long-term storage, keep the material in a freezer at -20°C. The container must be kept in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Solubility	Soluble in common organic solvents (THF, DCM, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.