Description

Vorapaxar Sulfate m-9 is a high-purity, non-peptidic active pharmaceutical ingredient (API) and a potent, selective antagonist of the protease-activated receptor-1 (PAR-1). This compound is critical for advanced pharmaceutical research and development, particularly in the field of antiplatelet and antithrombotic therapies. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development of novel cardiovascular drugs and clinical diagnostics.

Application

• Pharmaceutical API: Serves as the active ingredient in the formulation of finished dosage forms for antiplatelet therapy.
• Cardiovascular Research: A key tool compound for investigating PAR-1 mediated signaling pathways in thrombosis and atherosclerosis.
• Preclinical & Clinical Development: Used in the development and manufacturing of drug candidates targeting the prevention of atherothrombotic events.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and quality assurance (QA) laboratories for method development and validation.
• Biochemical Assays: Utilized in in vitro studies to selectively inhibit PAR-1 to understand its role in platelet aggregation and vascular biology.

Basic Information

Product Name	Vorapaxar Sulfate m-9
CAS No.	900161-11-7
Molecular Formula	C29H33FN2O4 • H2SO4
Molecular Weight	590.65 g/mol (free base: 492.58)
Synonyms	Vorapaxar sulfate; SCH 530348 sulfate; (1R,3aR,4aR,9bS)-6-Fluoro-1,2,3a,4,4a,5,9b,10-octahydro-1,4a-bis(3-methoxyphenyl)-7-methylpyrrolo[3,2-c]quinolin-8(1H)-one sulfate; PAR-1 antagonist; Antiplatelet agent Zontivity (brand name) related substance
EINECS	Contact for details

Quality Control

Our Vorapaxar Sulfate m-9 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identification by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure compliance with ICH guidelines and customer-specific requirements. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.