Description

(3A,5B,7A,12A)-24-[(Carboxymethyl)Amino]-1,12-Dihydroxy-24-Oxocholan-3-Yl B-D-Glucopyranosiduronic Acid is a high-purity, conjugated bile acid derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical intermediate and reference standard for studying bile acid metabolism, transporter interactions, and the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on hepatology, gastroenterology, and metabolic disease research.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quantifying bile acids and their metabolites in biological samples.
• Biochemical Research: Critical for in vitro and in vivo studies investigating the role of conjugated bile acids in digestion, cholesterol homeostasis, and signaling pathways.
• Drug Discovery Intermediate: Serves as a key synthetic building block for developing new therapeutic agents targeting Farnesoid X Receptor (FXR) and other nuclear receptors.
• Metabolite Identification: Employed as an authentic standard to identify and characterize novel bile acid conjugates in metabolomics and pharmacokinetic studies.
• Enzyme Substrate/Inhibitor Studies: Used to study the activity and inhibition of enzymes like bile salt hydrolase (BSH) and sulfotransferases.
• Cell Culture & Assay Development: Applied in cell-based assays to model bile acid transport and toxicity, aiding in the development of hepatoprotective drugs.

Basic Information

Item	Detail
Product Name	(3A,5B,7A,12A)-24-[(Carboxymethyl)Amino]-1,12-Dihydroxy-24-Oxocholan-3-Yl B-D-Glucopyranosiduronic Acid
CAS No.	99794-78-2
Molecular Formula	C32H51NO12
Molecular Weight	641.75 g/mol
Synonyms	Glycochenodeoxycholic Acid 3-O-Glucuronide; 3-Glucuronosyl-glycochenodeoxycholic Acid; GCDCA-3G; N-(3α,7α-Dihydroxy-24-oxo-5β-cholan-24-yl)glycine 3-O-β-D-Glucopyranosiduronic Acid; Glycochenodeoxycholate 3-O-β-D-Glucuronide; 3β-Glucuronosylglycochenodeoxycholate; Chenodeoxycholylglycine 3-O-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our (3A,5B,7A,12A)-24-[(Carboxymethyl)Amino]-1,12-Dihydroxy-24-Oxocholan-3-Yl B-D-Glucopyranosiduronic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); therefore, containers must be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.