Description

Exosurf is a synthetic pulmonary surfactant primarily composed of dipalmitoylphosphatidylcholine (DPPC) and hexadecanol, formulated with tyloxapol as a spreading agent. This compound is critical for reducing surface tension in the alveoli, preventing collapse and facilitating proper gas exchange in the lungs. It is an essential material for pharmaceutical R&D and manufacturing, particularly for developing treatments for respiratory distress syndrome (RDS) in neonates and acute respiratory conditions.

Application

• Pharmaceutical Active Ingredient: Core component in the formulation of synthetic lung surfactant therapies.
• Neonatal Respiratory Care: Research and production of medications for the prevention and treatment of Neonatal Respiratory Distress Syndrome (NRDS).
• Acute Respiratory Support: Development of therapeutic agents for Acute Respiratory Distress Syndrome (ARDS) in adults.
• Biomimetic Material Research: Used in studies modeling pulmonary interface mechanics and surfactant replacement therapies.
• Drug Delivery Systems: Potential excipient or carrier for pulmonary-administered drugs due to its alveolar spreading properties.
• Reference Standard: Serves as a quality control standard in analytical laboratories for surfactant-based pharmaceuticals.

Basic Information

Product Name	Exosurf
CAS No.	99732-49-7
Molecular Formula	Mixture (Primary: C40H80NO8P for DPPC)
Molecular Weight	Mixture (DPPC: 734.04 g/mol)
Synonyms	Exosurf Neonatal; Colfosceril Palmitate, Cetyl Alcohol, and Tyloxapol; Synthetic Lung Surfactant; Pulmonary Surfactant (Synthetic); Dipalmitoyl Phosphatidylcholine, Hexadecanol and Tyloxapol; CLSE (Calf Lung Surfactant Extract) Synthetic Analog; Colfosceril Palmitate Combination
EINECS	Contact for details

Quality Control

Our Exosurf is manufactured under strict quality management systems suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay of active components (DPPC, hexadecanol), and related substance profiling to ensure high purity and batch-to-batch consistency. A Certificate of Analysis (COA) detailing specifications and results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Description	White to off-white powder or solid mixture
Identification (IR/HPLC)	Conforms to reference standard
Assay (DPPC by HPLC)	≥ 95.0%
Assay (Hexadecanol by GC)	Specified range
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%
Bacterial Endotoxins	< 0.5 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.