Description

Boc-L-Leucine Thioamide is a protected amino acid derivative where the leucine side chain is modified with a thioamide functional group. This compound is a crucial building block in organic synthesis and peptide chemistry, particularly for introducing structural modifications and studying enzyme inhibition. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and the development of novel bioactive peptides.

Application

• Pharmaceutical Intermediates: Serves as a key synthon in the preparation of protease inhibitors and other therapeutic agents.
• Peptide Mimetics Research: Used to synthesize peptide analogs where the thioamide group replaces the oxoamide, altering stability and biological activity.
• Chemical Biology Probes: Employed in the study of enzyme mechanisms and protein-ligand interactions due to its modified backbone.
• Organocatalyst Development: Acts as a precursor or ligand in asymmetric synthesis for creating chiral compounds.
• Material Science: Potential use in the synthesis of functionalized polymers and advanced organic materials.

Basic Information

Product Name	Boc-L-Leucine Thioamide
CAS No.	99701-60-7
Molecular Formula	C11H22N2O2S
Molecular Weight	246.37 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-leucine thioamide; Boc-Leu-thioamide; (S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanethioamide; tert-Butyl (1S)-1-(aminothioxomethyl)-3-methylbutylcarbamate; N-Boc-L-leucinethioamide; L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, thioamide; Boc-L-leucine thioamide
EINECS	Contact for details

Quality Control

Our Boc-L-Leucine Thioamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic methods for structural confirmation, to ensure compliance with high-purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.