Description

(R)-(+)-Tolbinap CAS NO 99646-28-3 is a high-purity, chiral ligand belonging to the BINAP (2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl) family, specifically the (R)-(+)-enantiomer. This compound is critically important for its role in asymmetric catalysis, enabling the synthesis of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs). It is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in their synthetic processes.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical synthesis.
• Catalyst component for the production of enantiomerically pure agrochemicals and flavors/fragrances.
• Key reagent in academic and industrial research for developing new asymmetric catalytic methodologies.
• Used in the synthesis of chiral intermediates for antiviral and anticancer drug candidates.
• Facilitates enantioselective C-C bond-forming reactions in advanced organic synthesis.

Basic Information

Item	Detail
Product Name	(R)-(+)-Tolbinap
CAS No.	99646-28-3
Molecular Formula	C44H32P2
Molecular Weight	622.68 g/mol
Synonyms	(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl; (R)-DTB-BINAP; (R)-Tol-BINAP; (R)-(+)-DTB-BINAP; (R)-p-Tolyl-BINAP; (R)-(+)-Bis(di-p-tolylphosphino)binaphthyl; (R)-Tolbinap; (R)-BINAP derivative
EINECS	Contact for details

Quality Control

Our (R)-(+)-Tolbinap is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, 31P NMR, and 1H NMR, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This material is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.