Description

ω-1-Hydroxy Fentanyl is a key intermediate and metabolite in the synthesis and pharmacological study of fentanyl-related compounds. This compound is of significant importance for research and development in pharmaceutical chemistry, particularly in the investigation of metabolic pathways and the creation of novel analgesic agents. It is primarily utilized by pharmaceutical R&D laboratories, forensic science institutions, and analytical reference standard producers for method development and quality control.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of fentanyl analogs and related opioid receptor ligands.
• Metabolite Standard: Used as a certified reference material (CRM) in forensic and clinical toxicology for the detection and quantification of fentanyl metabolites.
• Pharmacological Research: Employed in studies investigating the metabolism, pharmacokinetics, and structure-activity relationships (SAR) of synthetic opioids.
• Analytical Method Development: Serves as a high-purity standard for calibrating HPLC, LC-MS/MS, and GC-MS systems in analytical laboratories.
• Regulatory Compliance Testing: Used by quality control laboratories to test for impurity profiles and ensure the safety of pharmaceutical products.

Basic Information

Product Name	ω-1-Hydroxy Fentanyl
CAS No.	99624-68-7
Molecular Formula	C₂₂H₂₈N₂O₂
Molecular Weight	352.47 g/mol
Synonyms	1-Hydroxy Fentanyl; 1'-Hydroxy Fentanyl; 4-Anilino-N-phenethylpiperidine-4-carboxylic acid methyl ester, 1-Hydroxy derivative; N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide, 1-Hydroxy; Fentanyl metabolite; ω-1-Hydroxyfentanyl; 4'-OH Fentanyl (common misnomer); 1-Hydroxy Fentanyl HCl (salt form)
EINECS	Contact for details

Quality Control

Our ω-1-Hydroxy Fentanyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets exacting standards for research and reference use. Certificates of Analysis (COA) with detailed chromatographic data and batch-specific results are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%
Assay (HPLC)	97.0% - 102.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.