Description

(S)-Flecainide is the single enantiomer of the class IC antiarrhythmic agent flecainide, characterized by its high stereochemical purity. This specific isomer is of significant interest in pharmaceutical research and development for its targeted pharmacological activity and potential for improved therapeutic profiles. It is primarily utilized by pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in advanced cardiac drug discovery, enantioselective synthesis, and the development of novel therapeutic entities.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of enantiomerically pure antiarrhythmic drugs.
• Cardiac Research: Used as a reference standard and active material in preclinical studies investigating sodium channel blockade and cardiac electrophysiology.
• Enantioselective Synthesis: Serves as a critical precursor for developing stereospecific formulations and studying structure-activity relationships (SAR).
• Analytical Standard: Employed in HPLC, LC-MS, and chiral chromatography for method development, validation, and quality control testing.
• Process Development: Used in scaling up and optimizing synthetic routes for the commercial production of (S)-Flecainide or related compounds.

Basic Information

Product Name	(S)-Flecainide
CAS No.	99495-92-8
Molecular Formula	C17H20F6N2O3
Molecular Weight	414.35 g/mol
Synonyms	(S)-Flecainide; (S)-N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide; (S)-1,2-Bis(2,2,2-trifluoroethoxy)-4-[[(2-piperidinylmethyl)amino]carbonyl]benzene; (S)-Flecainide Acetate (salt forms); Flecainide (S)-enantiomer; (S)-Flecainide free base; R 818 (S-enantiomer)
EINECS	Contact for details

Quality Control

Our (S)-Flecainide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, residual solvents, and related substances are available for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.