Description

(R)-(+)-Propafenone Hydrochloride CAS NO 107381-35-1 is the single enantiomer form of the Class 1C antiarrhythmic agent, propafenone hydrochloride. This high-purity chiral intermediate is critical for the research and development of stereoselective pharmaceuticals targeting cardiac arrhythmias. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on cardiovascular drug discovery and enantiomer-specific pharmacology studies.

Application

• Active Pharmaceutical Ingredient (API) Intermediate for the synthesis of enantiomerically pure (R)-propafenone.
• Pharmacological Reference Standard in cardiovascular research to study the stereospecific activity, metabolism, and pharmacokinetics of propafenone enantiomers.
• Process Development for the manufacture of chiral antiarrhythmic drugs, ensuring regulatory compliance for enantiomeric purity.
• Analytical Method Development as a high-purity standard for HPLC, LC-MS, and chiral separation techniques.
• Preclinical and Clinical Research material for investigating the efficacy and safety profile of the (R)-enantiomer.
• Impurity Standard in the quality control of racemic propafenone hydrochloride batches to monitor enantiomeric excess.

Basic Information

Product Name	(R)-(+)-Propafenone Hydrochloride
CAS No.	107381-35-1
Molecular Formula	C21H28ClNO3
Molecular Weight	377.90 g/mol
Synonyms	(R)-(+)-Propafenone HCl; (2R)-1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropan-2-one Hydrochloride; (R)-Propafenone Hydrochloride; Dexpropafenone Hydrochloride; (R)-Propafenone HCl; (+)-Propafenone Hydrochloride; S-Propafenone Hydrochloride (Note: Often confused; S- is the cutomer, R- is the distomer for sodium channel blockade); 1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenyl-2-propanone Hydrochloride, (R)-
EINECS	Contact for details

Quality Control

Our (R)-(+)-Propafenone Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling via HPLC and spectroscopic methods, to ensure it meets stringent standards for pharmaceutical research. A Certificate of Analysis (COA) detailing specific results for purity, enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.