Description

(S)-(-)-Propafenone Hydrochloride is the single enantiomer form of the established Class IC antiarrhythmic agent. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure cardiovascular pharmaceuticals. It is primarily required by advanced pharmaceutical R&D laboratories and fine chemical manufacturers focused on producing targeted, stereospecific drug substances with improved therapeutic profiles and reduced side-effect potential.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of the (S)-enantiomer of Propafenone HCl, a sodium channel blocker.
• Cardiovascular Drug Research: Essential reference standard and starting material for preclinical and clinical studies of enantiopure antiarrhythmic agents.
• Process Chemistry & Scale-Up: Used in the development and optimization of asymmetric synthesis routes for commercial pharmaceutical production.
• Analytical Standard: Serves as a high-purity standard for HPLC, chiral chromatography, and spectroscopic methods to ensure quality control of the final API.
• Regulatory Filings: Provides the necessary enantiomerically pure material for impurity profiling and stability studies required by FDA, EMA, and other global health authorities.

Basic Information

Product Name	(S)-(-)-Propafenone Hydrochloride
CAS No.	107381-36-2
Molecular Formula	C21H28ClNO3
Molecular Weight	377.90 g/mol
Synonyms	(S)-Propafenone HCl; (S)-1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone Hydrochloride; (S)-(-)-2'-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone Hydrochloride; (S)-Propafenone Hydrochloride; Dexpropafenone Hydrochloride; S-Propafenone Hydrochloride; (S)-(-)-Propafenone HCl; SR-33557 (S-enantiomer)
EINECS	Contact for details

Quality Control

Our (S)-(-)-Propafenone Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and enantiomeric excess, typically exceeding 99.0% by HPLC. Certificates of Analysis (COA) are provided, detailing comprehensive analytical results including chiral purity, residual solvents, and related substances. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 99.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.1%; Total impurities ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.