Description

(S)-Propafenone CAS NO 107381-32-8 is the single enantiomer of the class 1C antiarrhythmic agent propafenone. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure pharmaceuticals targeting cardiac arrhythmias. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on producing advanced cardiovascular drugs with improved efficacy and reduced side-effect profiles.

Application

• Key chiral building block for the synthesis of enantiopure (S)-Propafenone Hydrochloride API.
• Critical intermediate in pharmaceutical research for novel antiarrhythmic drug development.
• Used in preclinical and clinical studies to investigate the stereospecific pharmacokinetics and pharmacodynamics of propafenone.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Starting material for the production of deuterated or other isotopically labeled propafenone analogs for metabolic studies.
• Essential for academic and industrial research into cardiac sodium channel blockers.

Basic Information

Product Name	(S)-Propafenone
CAS No.	107381-32-8
Molecular Formula	C21H27NO3
Molecular Weight	341.45 g/mol
Synonyms	(S)-1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone; (S)-Propafenone Base; (2S)-1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one; Dexpropafenone; S-Propafenone; Propafenone S-Enantiomer; (S)-Propafenon
EINECS	Contact for details

Quality Control

Our (S)-Propafenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing specifications such as chiral purity (HPLC), chemical purity (HPLC), and residual solvents (GC) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.