Description

(R)-Propafenone CAS NO 107381-31-7 is the single enantiomer of the class Ic antiarrhythmic agent propafenone. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure pharmaceuticals, where the specific stereochemistry is essential for targeted biological activity and reduced side-effect profiles. It is primarily required by advanced pharmaceutical R&D laboratories and fine chemical manufacturers engaged in producing novel cardiovascular drugs and conducting metabolic studies.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the production of enantiopure (R)-propafenone hydrochloride.
• Cardiovascular Drug Research & Development: Used in preclinical and clinical studies to investigate stereospecific effects on cardiac sodium channels.
• Metabolite and Impurity Reference Standard: Serves as a critical analytical standard in HPLC and LC-MS methods for quality control and pharmacokinetic studies.
• Asymmetric Synthesis & Catalysis Studies: Valuable substrate for developing and testing new chiral separation techniques and synthetic methodologies.
• Regulatory Submission Batches: Employed in the manufacture of drug substance batches for regulatory filings (e.g., FDA, EMA) requiring defined enantiomeric purity.

Basic Information

Product Name	(R)-Propafenone
CAS No.	107381-31-7
Molecular Formula	C21H27NO3
Molecular Weight	341.45 g/mol
Synonyms	(R)-1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone; (R)-Propafenone Base; Dexpropafenone; (2R)-1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone; (R)-Propafenone Free Base; UNII-8K6299P8PQ; (R)-(-)-Propafenone
EINECS	Contact for details

Quality Control

Our (R)-Propafenone is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, to ensure it meets the high-purity standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.