Description

Hydroxyquinidine Gluconate is a high-purity, pharmaceutically relevant salt form of the cinchona alkaloid derivative, hydroxyquinidine. This compound is valued for its specific stereochemistry and pharmacological activity, serving as a critical intermediate and reference standard in advanced research and development. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in the synthesis of specialized therapeutics, method development, and quality control. The product is supplied with full traceability and documentation to meet the stringent demands of regulated industries.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of antiarrhythmic and antimalarial drug candidates.
• Analytical Reference Standard: Used for method development, validation, and quantification in HPLC and LC-MS assays for quality control laboratories.
• Biochemical Research: Employed in studies of ion channel modulation and as a tool compound in cardiac electrophysiology research.
• Process Development: Serves as a starting material or catalyst in asymmetric synthesis for producing enantiomerically pure compounds.
• Pharmacopoeial Standards: Potential use in the preparation of secondary standards for compliance with pharmacopoeial monographs (e.g., USP, EP).

Basic Information

Product Name	Hydroxyquinidine Gluconate
CAS No.	18253-58-2
Molecular Formula	C₂₆H₃₂N₂O₄ • C₆H₁₂O₇
Molecular Weight	604.65 g/mol
Synonyms	10-Hydroxyquinidine D-gluconate; (8S,9R)-10,11-Dihydro-6'-hydroxycinchonan-9-ol D-gluconate; Hydroxyquinidine gluconate salt; Quinidine, 10-hydroxy-, gluconate (salt); Cinchonan-9-ol, 10,11-dihydro-6'-hydroxy-, (8S,9R)-, D-gluconate (salt)
EINECS	Contact for details

Quality Control

Our Hydroxyquinidine Gluconate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets high-purity standards suitable for pharmaceutical research. A Certificate of Analysis (COA) detailing specific results for identity, potency, and related substances is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.