Description

(R)-Flecainide CAS NO 99495-90-6 is the single enantiomer of the class IC antiarrhythmic agent flecainide, characterized by its specific (R)-configuration. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereoselective pharmacology and the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced cardiovascular drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiopure flecainide and related antiarrhythmic compounds.
• Cardiovascular Research: Used as a reference standard and active material in preclinical studies to investigate the stereospecific effects on cardiac sodium channels.
• Process Development: Serves as a critical starting material or intermediate in the development and scale-up of asymmetric synthesis routes for chiral drugs.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for method development and quality control in HPLC and chiral separation techniques.
• Metabolite Studies: Utilized in the synthesis and identification of specific stereoisomeric metabolites for pharmacokinetic and toxicological profiling.

Basic Information

Product Name	(R)-Flecainide
CAS No.	99495-90-6
Molecular Formula	C17H20F6N2O3
Molecular Weight	414.35 g/mol
Synonyms	(R)-N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide; (R)-Flecainide Acetate (salt form); (R)-Tambocor; (R)-Flecainide enantiomer; R-Flecainide; (2R)-N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide; (R)-Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-; (R)-Flecainide base
EINECS	Contact for details

Quality Control

Our (R)-Flecainide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity (typically ≥98.5% by HPLC), enantiomeric excess (ee), and residual solvent levels is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is stable under these conditions for extended periods. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.