Description

5-Formyl-5,6,7,8-Tetrahydromethanopterin is a specialized biochemical cofactor and a key intermediate in the C1 metabolic pathways of methanogenic and sulfate-reducing archaea. This compound matters for researchers and manufacturers focused on enzymology, microbial metabolism, and the development of novel biocatalytic processes. It is primarily needed by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in advanced metabolic studies and enzyme mechanism investigations.

Application

• Biochemical Research: Critical substrate for studying formylmethanofuran dehydrogenase and other enzymes in archaeal methanogenesis.
• Enzyme Mechanism Studies: Used to elucidate the catalytic cycles and cofactor requirements of tetrahydromethanopterin-dependent enzymes.
• Metabolic Pathway Analysis: Essential for in vitro reconstruction and analysis of C1 transfer pathways in anaerobic microorganisms.
• Reference Standard: Serves as a high-purity analytical standard for chromatography (HPLC, LC-MS) in research and quality control laboratories.
• Biocatalyst Development: Potential use in developing engineered enzymatic systems for synthetic biology applications.

Basic Information

Product Name	5-Formyl-5,6,7,8-Tetrahydromethanopterin
CAS No.	99451-79-3
Molecular Formula	C30H44N5O19P3
Molecular Weight	895.62 g/mol
Synonyms	5-Formyl-H4MPT; 5-Formyltetrahydromethanopterin; Formylmethanopterin; 5-Formyl-5,6,7,8-tetrahydro-methanopterin; 5-Formyl-H4MPT (oxidized form); 5-Formyl-5,6,7,8-tetrahydromethanopterin (F-H4MPT); 5-Formyl-5,6,7,8-tetrahydromethanopterin (F420-dependent)
EINECS	Contact for details

Quality Control

Our 5-Formyl-5,6,7,8-Tetrahydromethanopterin is produced under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and spectroscopic techniques, are validated to provide reliable data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers should be allowed to equilibrate to room temperature before opening to minimize moisture ingress, and handling should be performed in a controlled, dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.