Description

Methyl 4-Bromo-L-Phenylalaninate Hydrochloride is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of 4-bromo-L-phenylalanine. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing the 4-bromophenylalanine moiety into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of peptides, peptidomimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the non-natural amino acid 4-bromo-L-phenylalanine into peptide sequences.
• Proteomics & Biochemical Research: Serves as a precursor for labeled amino acids or as a building block for creating enzyme inhibitors and receptor ligands in biochemical studies.
• Chemical Biology Tool Development: Employed in the synthesis of chemical probes and affinity tags for studying protein-protein interactions and cellular processes.
• Material Science: Potential use as a monomer or precursor for specialized polymers and advanced materials with unique optical or electronic properties.

Basic Information

Item	Detail
Product Name	Methyl 4-Bromo-L-Phenylalaninate Hydrochloride
CAS No.	99359-32-7
Molecular Formula	C10H13BrNO2 • HCl
Molecular Weight	308.58 g/mol
Synonyms	L-Phenylalanine, 4-bromo-, methyl ester, hydrochloride; Methyl (2S)-2-amino-3-(4-bromophenyl)propanoate hydrochloride; 4-Bromo-L-phenylalanine methyl ester hydrochloride; (S)-Methyl 2-amino-3-(4-bromophenyl)propanoate hydrochloride; Methyl ester of 4-Bromo-L-phenylalanine hydrochloride; Boc-4-Bromo-L-Phe-OMe•HCl precursor; Fmoc-4-Bromo-L-Phe-OMe•HCl precursor
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromo-L-Phenylalaninate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.