Description

Boc-L-Phenylalanine Thioamide is a protected amino acid derivative where the amine group is shielded by a tert-butoxycarbonyl (Boc) group and the carboxylic acid is converted to a thioamide. This specific functionalization makes it a valuable key chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including peptidomimetics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug candidates and bioactive peptides.
• Peptidomimetic Research: Used to create thioamide-containing peptide analogs to study protein structure, function, and stability.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting specific enzymes.
• Organocatalyst Synthesis: Employed in the preparation of chiral catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create labeled or modified amino acids for studying biological pathways.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	Boc-L-Phenylalanine Thioamide
CAS No.	99281-95-5
Molecular Formula	C₁₄H₂₀N₂O₂S
Molecular Weight	280.39 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanethioamide; N-(tert-Butoxycarbonyl)-L-phenylalaninethioamide; Boc-Phe-thioamide; Boc-L-Phe-NH₂(S); N-Boc-L-phenylalaninethioamide; tert-Butyl (1S)-1-(aminothioxomethyl)-2-phenylethylcarbamate; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, thioamide
EINECS	Contact for details

Quality Control

Our Boc-L-Phenylalanine Thioamide is manufactured under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.