Description

(S)-Boc-2-Amino-3-Phenyl-Propionitrile is a high-purity, chiral building block of significant importance in advanced organic synthesis. Its core value lies in providing a protected amino acid derivative with a nitrile functional group, enabling precise stereochemical control in the construction of complex molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme inhibitors, and other biologically active compounds.
• Peptidomimetics Research: Used to incorporate non-natural amino acid residues into peptide chains to enhance metabolic stability and binding affinity.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure products.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Chemical Biology: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical studies.
• Custom Synthesis: A fundamental building block for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	(S)-Boc-2-Amino-3-Phenyl-Propionitrile
CAS No.	99281-90-0
Molecular Formula	C₁₄H₁₈N₂O₂
Molecular Weight	246.31 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanenitrile; (S)-Boc-Phe-CN; (S)-N-Boc-2-Amino-3-phenylpropionitrile; (S)-N-(tert-Butoxycarbonyl)-2-amino-3-phenylpropionitrile; (S)-tert-Butyl (1-cyano-2-phenylethyl)carbamate; Boc-L-Phenylalaninenitrile; Boc-Phe(CN)-OH (deprotonated nitrile form); L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, nitrile
EINECS	Contact for details

Quality Control

Our (S)-Boc-2-Amino-3-Phenyl-Propionitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.