Description

Tos-Ala-Oh CAS NO 99076-56-9 is a high-purity, protected amino acid derivative, specifically the tosyl-protected form of L-alanine carboxylic acid. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS) and other advanced organic synthesis workflows, enabling precise molecular construction. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for developing novel peptides and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of alanine residues in the synthesis of complex peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Bioconjugation: Acts as a linker or spacer molecule in the conjugation of peptides to other biomolecules, drugs, or surfaces.
• Fine Chemical Synthesis: Serves as a chiral synthon for the asymmetric synthesis of more complex organic molecules beyond peptides.
• Academic & Industrial Research: A fundamental reagent for studying peptide structure, function, and stability in biochemical and medicinal chemistry laboratories.

Basic Information

Product Name	Tos-Ala-Oh
CAS No.	99076-56-9
Molecular Formula	C10H13NO4S
Molecular Weight	243.28 g/mol
Synonyms	N-(p-Toluenesulfonyl)-L-alanine; L-Alanine, N-[(4-methylphenyl)sulfonyl]-; Tosyl-L-alanine; N-Tosyl-L-alanine; N-Tosylalanine; N-p-Tosyl-L-alanine; (2S)-2-[(4-Methylphenyl)sulfonylamino]propanoic acid; TOS-ALA-OH
EINECS	Contact for details

Quality Control

Our Tos-Ala-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, chiral purity analysis, and identification by IR and NMR. We provide full traceability and support cGMP-compliant applications. A detailed Certificate of Analysis (COA) is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.