Description

N,N'-Bis(9-Fluorenylmethyloxycarbonyl)-L-Histidine is a specialized, protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, selectively protected building blocks for complex biomolecule construction. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected L-histidine derivative for the controlled assembly of peptides, preventing unwanted side reactions during chain elongation.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide drugs, including hormones, enzyme inhibitors, and targeted therapies.
• Bioconjugation: Acts as a precursor for creating histidine-tagged molecules or for introducing specific functional handles onto peptides and proteins.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Biochemical Research: Essential for studying histidine's role in enzyme active sites, metal binding, and protein structure-function relationships using synthetic analogs.
• Custom Peptide Service: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing services to clients worldwide.

Basic Information

Product Name	N,N'-Bis(9-Fluorenylmethyloxycarbonyl)-L-Histidine
CAS No.	98929-98-7
Molecular Formula	C37H31N3O6
Molecular Weight	613.66 g/mol
Synonyms	Fmoc-His(Fmoc)-OH; Nα,Nπ-Bis-Fmoc-L-histidine; Nα,Nim-Bis(9-fluorenylmethoxycarbonyl)-L-histidine; L-Histidine, N,N'-bis(9H-fluoren-9-ylmethoxy)carbonyl]-; Bis-Fmoc-L-histidine; Fmoc-His(Nπ-Fmoc)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-1H-imidazol-4-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our N,N'-Bis(9-Fluorenylmethyloxycarbonyl)-L-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.