Description

Substance P (6-11), Pglu(6)-Phe(8)-Psi-(Methyleneoxy)-Gly(9)- CAS NO 98900-29-9 is a synthetic, biologically active peptide fragment derived from the neuropeptide Substance P. This compound is specifically engineered as a potent and selective antagonist for the neurokinin-1 (NK1) receptor, offering significant research value in neuropharmacology. It is an essential tool for researchers and pharmaceutical developers in neuroscience, pain management, and inflammation studies, enabling the investigation of receptor mechanisms and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective NK1 receptor antagonist for studying the role of Substance P in pain signaling, stress responses, and emotional behavior.
• Pharmacological Assay Development: Used as a reference standard in competitive binding assays and functional studies to screen and characterize new drug candidates targeting the NK1 receptor.
• Inflammation and Immunology Studies: Investigating the pro-inflammatory effects mediated by Substance P and its receptor in various disease models.
• Drug Discovery & Preclinical Testing: A key biochemical tool for validating drug targets and evaluating the efficacy of potential neurokinin receptor antagonists in vitro and in vivo.
• Academic and Institutional Research: Supplied to universities and research institutes for fundamental studies in neurochemistry and peptide biology.
• Biochemical Reagent Manufacturing: Sourced by companies producing high-purity reagents and assay kits for the life science research market.

Basic Information

Product Name	Substance P (6-11), Pglu(6)-Phe(8)-Psi-(Methyleneoxy)-Gly(9)- CAS NO 98900-29-9
CAS No.	98900-29-9
Molecular Formula	C38H51N9O9
Molecular Weight	777.87 g/mol
Synonyms	Substance P (6-11) analog; [pGlu6, Phe8, ψ(CH2O)Gly9]-Substance P (6-11); (6-11)-Substance P, [pGlu6,Phe8,ψ(CH2O)Gly9]-; NK1 Receptor Antagonist (6-11); pGlu-Phe-Phe-Gly-Leu-Met-NH2 analog; SP (6-11) pseudopeptide; Neurokinin-1 Antagonist Fragment; [pGlu6,Phe8,ψ(CH2NH)Gly9]-Substance P(6-11) (common variant notation)
EINECS	Contact for details

Quality Control

Our Substance P (6-11) analog is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.