Description

Rac Propanolol-D7 is a deuterated isotopologue of the non-selective β-adrenergic receptor blocker, propranolol, where seven hydrogen atoms are replaced with deuterium. This compound is of critical importance as a high-purity internal standard for quantitative bioanalytical methods, ensuring accuracy and precision in mass spectrometry-based analyses. It is primarily needed by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, clinical research, and forensic toxicology.

Application

• Primary use as an internal standard for the quantification of propranolol in biological matrices (e.g., plasma, serum, urine) via LC-MS/MS and GC-MS.
• Essential for drug metabolism and pharmacokinetic (DMPK) studies to understand the absorption, distribution, metabolism, and excretion of propranolol.
• Critical component in clinical research and therapeutic drug monitoring (TDM) protocols to ensure accurate patient dosing.
• Used in forensic and anti-doping analysis for the definitive identification and quantification of propranolol.
• Supports pharmaceutical development and stability testing of propranolol-containing formulations.
• Facilitates isotope dilution mass spectrometry (IDMS), a gold-standard technique for achieving high metrological accuracy.

Basic Information

Product Name	Rac Propanolol-D7
CAS No.	98897-23-5
Molecular Formula	C₁₆H₁₄D₇NO₂
Molecular Weight	266.39 g/mol
Synonyms	Propranolol-d7; (±)-Propranolol-d7; 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol-d7; DL-Propranolol-d7; rac-Propranolol-d7; Inderal-d7; ICI 45520-d7; 1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol-d7
EINECS	Contact for details

Quality Control

Every batch of Rac Propanolol-D7 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR (¹H, ¹³C) and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and solvent content. Our quality commitment aligns with the standards expected for pharmaceutical reference standards and analytical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.