Description

Transforming Growth Factor-Beta1, Human is a potent, multifunctional cytokine that plays a critical role in regulating cell growth, proliferation, differentiation, and apoptosis. This high-purity recombinant protein is essential for advanced biomedical research and therapeutic development, offering precise control over cellular signaling pathways. It is a fundamental reagent for researchers and manufacturers in the fields of regenerative medicine, cancer biology, immunology, and stem cell research, where consistent quality and biological activity are paramount.

Application

• Cell Culture & Stem Cell Research: Used to maintain pluripotency in embryonic stem cells and to direct differentiation into specific lineages (e.g., chondrocytes, osteoblasts).
• Tissue Engineering & Regenerative Medicine: Incorporated into scaffolds and matrices to promote tissue repair, wound healing, and cartilage/bone formation.
• Cancer Research: Investigated for its dual role in tumor suppression and promotion, particularly in studying epithelial-mesenchymal transition (EMT) and metastasis.
• Immunology Studies: Employed to study immune regulation, including T-cell differentiation and the function of regulatory T cells (Tregs).
• Biopharmaceutical Development: Serves as a critical raw material or reference standard in the development of biologics and cell-based therapies.
• Biochemical Assays: Used as a key component in ELISA kits, activity assays, and signaling pathway studies to quantify TGF-β1 levels or activity.

Basic Information

Product Name	Transforming Growth Factor-Beta1, Human
CAS No.	98726-64-8
Molecular Formula	C519H805N139O157S9
Molecular Weight	~12.5 kDa (monomer, unprocessed precursor); ~25 kDa (disulfide-linked homodimer, active form)
Synonyms	TGF-β1; TGFB1; TGF-beta 1; Transforming Growth Factor β-1; CED; DPD1; TGFB; TGFbeta; Latency-associated peptide (LAP); Cartilage-inducing factor A
EINECS	Contact for details

Quality Control

Our Transforming Growth Factor-Beta1, Human is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each lot undergoes comprehensive analytical testing, including SDS-PAGE, HPLC, and mass spectrometry for purity assessment, and cell-based bioassays (e.g., using mink lung epithelial cells) to confirm specific activity. Certificates of Analysis (COA) detailing purity, endotoxin levels, sterility, and biological potency are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C to -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	> 95%
Purity (RP-HPLC)	> 98%
Molecular Weight	~25 kDa (reduced)
Biological Activity	ED50 ≤ 2.0 ng/mL (inhibition of Mv1Lu cell proliferation)
Endotoxin Level	< 1.0 EU/μg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.