Description

(S)-Ibuprofen-Acyl-β-D-Glucuronide CAS NO 98649-76-4 is a specific, high-purity metabolite of the non-steroidal anti-inflammatory drug (NSAID) (S)-ibuprofen. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in bioanalytical method development, metabolite identification, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of ibuprofen metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance mechanisms, and exposure levels of the active (S)-enantiomer of ibuprofen.
• Bioanalytical Method Development: Essential for developing and validating sensitive LC-MS/MS or HPLC methods for pharmacokinetic and toxicokinetic studies.
• Regulatory Submissions: Provides definitive characterization data required for Investigational New Drug (IND) and New Drug Application (NDA) filings with agencies like the FDA and EMA.
• Enantioselective Metabolism Research: Aids in studying the stereoselective glucuronidation and disposition of ibuprofen enantiomers.
• In vitro Metabolism Studies: Used with hepatocyte or microsomal incubations to elucidate phase II conjugation pathways.

Basic Information

Product Name	(S)-Ibuprofen-Acyl-β-D-Glucuronide
CAS No.	98649-76-4
Molecular Formula	C19H26O8
Molecular Weight	382.41 g/mol
Synonyms	(S)-Ibuprofen Acyl Glucuronide; (S)-Ibuprofen 1-O-β-Acyl Glucuronide; (2S)-2-[4-(2-Methylpropyl)phenyl]propanoic acid β-D-Glucopyranuronic Acid Ester; Dexibuprofen Acyl Glucuronide; (S)-(+)-Ibuprofen Acyl-β-D-Glucuronide; S-Ibuprofen AG; Dexibuprofen 1-O-β-Acyl Glucuronide
EINECS	Contact for details

Quality Control

Our (S)-Ibuprofen-Acyl-β-D-Glucuronide is manufactured under strict quality systems to ensure the highest standards of purity and identity required for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including HPLC, LC-MS, and NMR for identity confirmation, purity assessment, and impurity profiling. We adhere to relevant industry guidelines to support your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.