Description

Ropivacaine-Et-R CAS NO 98626-60-9 is a high-purity enantiomer of the widely used long-acting local anesthetic, Ropivacaine. This specific stereoisomer is critical for pharmaceutical research and development, particularly in studying stereoselective pharmacokinetics, pharmacodynamics, and receptor interactions. It is an essential reference standard and key intermediate for manufacturers and research institutions focused on developing novel anesthetic formulations, conducting chiral separations, and performing rigorous quality control testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification, assay, and impurity profiling of Ropivacaine in active pharmaceutical ingredient (API) and finished drug product quality control.
• Chiral Research & Development: Used as a critical material in stereochemistry studies to investigate the distinct biological activity, metabolism, and toxicity profile of the R-enantiomer compared to the S-enantiomer.
• Analytical Method Development: Employed in developing and validating sophisticated analytical methods, such as chiral HPLC, for the precise separation and quantification of Ropivacaine enantiomers.
• Metabolite Synthesis & Studies: Acts as a precursor or standard in the synthesis and analysis of Ropivacaine metabolites for pharmacokinetic and toxicological research.
• Formulation Development: Utilized in preclinical and formulation studies for novel local anesthetic delivery systems, including sustained-release formulations.
• Regulatory Submissions: Provides essential data and materials for regulatory filings (e.g., with FDA, EMA) requiring detailed characterization of stereoisomers.

Basic Information

Product Name	Ropivacaine-Et-R
CAS No.	98626-60-9
Molecular Formula	C17H26N2O
Molecular Weight	274.40 g/mol
Synonyms	(R)-Ropivacaine; (R)-1-Propyl-2',6'-pipecoloxylidide; (R)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide; Ropivacaine R-isomer; Ropivacaine Enantiomer R; (-)-Ropivacaine; LEAF 16004; UNII-7IO5LYA57N
EINECS	Contact for details

Quality Control

Our Ropivacaine-Et-R is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high standards for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as chiral purity, enantiomeric excess, and related substances by validated methods like HPLC and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.