Description

Parathyroid Hormone (1-34), Rat is a synthetic polypeptide fragment corresponding to the biologically active N-terminal region of the native rat parathyroid hormone. This compound is a critical research tool for studying calcium and phosphate metabolism, bone physiology, and renal function. It is essential for researchers in endocrinology, bone biology, and pharmaceutical development, particularly for in vitro and in vivo studies involving rodent models.

Application

• Endocrine Research: Investigating the role of PTH in calcium homeostasis, bone remodeling, and vitamin D metabolism.
• Bone Disease Studies: Used in preclinical models for osteoporosis, hyperparathyroidism, and other metabolic bone disorders.
• Receptor Binding Assays: Serves as a high-affinity ligand for characterizing and studying PTH/PTHrP receptors.
• Cell Signaling Pathways: Activation of adenylate cyclase and phospholipase C pathways in target cells (osteoblasts, renal cells).
• Pharmaceutical Screening: A reference standard in the development and testing of PTH analogs and receptor antagonists.
• Physiological Studies: Elucidating the differential effects of intermittent vs. continuous PTH exposure on bone formation and resorption.

Basic Information

Product Name	Parathyroid Hormone (1-34), Rat
CAS No.	98614-76-7
Molecular Formula	C₁₈₁H₂₉₁N₅₅O₅₁S₂
Molecular Weight	~4117.6 g/mol
Synonyms	PTH (1-34), Rat; Rat Parathyroid Hormone (1-34); rPTH(1-34); Parathyrin (1-34), Rat; N-terminal Parathyroid Hormone Fragment; PTH 1-34 (Rat); Teriparatide (Rat Sequence); H2N-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-COOH (Rat)
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (1-34), Rat is manufactured under stringent conditions suitable for research applications. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and endotoxin testing. Certificates of Analysis (COA) detailing purity, peptide content, and biological activity are provided to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Endotoxin	< 10 EU/mg
Biological Activity	Stimulates cAMP production in osteogenic cells

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.