Description

(R)-5-Bromomethyl-2-Pyrrolidinone is a high-purity chiral building block and versatile synthetic intermediate. Its value lies in its reactive bromomethyl group and defined stereochemistry, enabling the efficient construction of complex, optically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Synthesis: A key chiral intermediate for the production of enantiomerically pure drugs, including potential antiviral, neurological, and cardiovascular agents.
• Protease Inhibitor Development: Used in the research and synthesis of inhibitors targeting various proteases, leveraging the pyrrolidinone scaffold.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Peptidomimetic Chemistry: Incorporated into peptide analogs to enhance stability, bioavailability, and biological activity.
• Fine Chemical & Agrochemical Intermediates: Employed in the multi-step synthesis of specialized, high-value chemicals for various industrial applications.
• Academic & Process R&D: A valuable reagent for methodological studies in organic synthesis and scale-up process development.

Basic Information

Product Name	(R)-5-Bromomethyl-2-Pyrrolidinone
CAS No.	98612-60-3
Molecular Formula	C5H8BrNO
Molecular Weight	178.03 g/mol
Synonyms	(R)-5-(Bromomethyl)-2-pyrrolidinone; (5R)-5-(Bromomethyl)-2-pyrrolidinone; (R)-5-(Bromomethyl)pyrrolidin-2-one; (R)-α-Bromomethyl-γ-butyrolactam; (R)-NSC 339586; 2-Pyrrolidinone, 5-(bromomethyl)-, (5R)-; (R)-5-Bromomethyl-2-oxopyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-5-Bromomethyl-2-Pyrrolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.