Description

Alprenolol-Nbd is a specialized fluorescent-labeled derivative of the β-blocker alprenolol, primarily used as a high-affinity molecular probe in biochemical research. Its core value lies in enabling the visualization and quantification of β-adrenergic receptor binding and activity through advanced fluorescence techniques. This compound is essential for researchers and developers in the pharmaceutical and life sciences sectors, particularly those focused on cardiovascular drug discovery, receptor pharmacology, and cellular signaling pathways. The product is identified by the CAS registry number 98496-22-1.

Application

• β-Adrenergic Receptor Research: Acts as a fluorescent tracer for studying receptor density, localization, and binding kinetics in vitro.
• High-Throughput Screening (HTS): Utilized in fluorescence-based assays to identify and characterize new β-blocker drug candidates.
• Cellular Imaging: Enables direct visualization of receptor distribution and internalization processes in live or fixed cells using fluorescence microscopy.
• Competitive Binding Assays: Serves as a labeled ligand in displacement studies to determine the potency and affinity of unlabeled compounds.
• Pharmacological Profiling: Supports the investigation of subtype selectivity and functional responses of β-adrenergic receptors.
• Biomarker Development: Potential use in developing diagnostic tools for conditions related to adrenergic system dysregulation.

Basic Information

Product Name	Alprenolol-Nbd
CAS No.	98496-22-1
Molecular Formula	C24H29N3O4
Molecular Weight	423.51 g/mol
Synonyms	NBD-Alprenolol; 4-(2-Hydroxy-3-[(1-methylethyl)amino]propoxy)-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)benzenecarboximidamide; Alprenolol labeled with NBD; Alprenolol-NBD conjugate; Fluorescent Alprenolol; β-adrenergic receptor fluorescent probe
EINECS	Contact for details

Quality Control

Every batch of Alprenolol-Nbd is produced and analyzed under strict quality management protocols to ensure the highest standards of purity and performance for research applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and spectroscopic identification, to ensure consistency and reliability. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Allow the vial to equilibrate to room temperature before opening to minimize condensation. For long-term storage, consider under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers
Fluorescence Properties	Excitation ~465-480 nm, Emission ~520-550 nm (solvent dependent)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.