Description

2-Pentynoyl-Coenzyme A is a specialized biochemical reagent featuring a terminal alkyne moiety on the acyl chain. This compound serves as a critical intermediate in the study of fatty acid metabolism and enzyme mechanisms, particularly for probing the activity of acyl-CoA dehydrogenases and synthetases. It is essential for researchers and manufacturers in the fields of biochemical research, pharmaceutical development, and diagnostic enzyme production who require high-purity, well-characterized coenzyme A derivatives.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study fatty acid oxidation pathways and mitochondrial function.
• Pharmaceutical Development: Serves as a key intermediate or tool compound in the discovery of metabolic disorder therapeutics and enzyme-targeted drugs.
• Diagnostic Reagent Manufacturing: Employed in the production of test kits for inborn errors of metabolism, such as disorders of fatty acid β-oxidation.
• Enzyme Mechanism Studies: Utilized to investigate the substrate specificity and catalytic mechanism of acyl-CoA processing enzymes due to its alkyne functional group.
• Metabolomics & Proteomics: Acts as a chemical probe for activity-based protein profiling (ABPP) to identify and characterize active enzymes in complex biological samples.
• Academic & Institutional Laboratories: Fundamental tool for teaching and advanced research in biochemistry and molecular biology.

Basic Information

Product Name	2-Pentynoyl-Coenzyme A
CAS No.	98482-18-9
Molecular Formula	C₂₆H₄₂N₇O₁₇P₃S
Molecular Weight	897.70 g/mol
Synonyms	2-Pentynoyl-CoA; 2-Pentynoyl Coenzyme A; Coenzyme A, S-(2-pentynoate); Pent-2-ynoyl-coenzyme A; 2-Pentynoyl-Coenzyme A sodium salt (if applicable); S-(2-Pentynoyl)coenzyme A; 2-Butyl-2-ynoyl-CoA; Acetylene fatty acyl-CoA analog
EINECS	Contact for details

Quality Control

Our 2-Pentynoyl-Coenzyme A is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via mass spectrometry (MS) and/or NMR. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For custom purity grades or bulk manufacturing requirements, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity (Enzymatic Assay)	Conforms (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.