Description

(Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (Bovine) CAS NO 98474-60-3 is a specific, enzymatically modified peptide fragment derived from bovine myelin basic protein (MBP). This compound is of significant value in immunological and neurological research, serving as a critical antigenic determinant. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on studying autoimmune diseases such as multiple sclerosis (MS). The peptide's defined sequence allows for precise investigation into T-cell epitope mapping and the pathogenesis of demyelinating disorders.

Application

• Immunological Research: Key reagent for studying T-cell activation and epitope specificity in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis.
• Autoimmune Disease Studies: Used as a target antigen in assays designed to understand the immune response against myelin in conditions like MS.
• Vaccine Development: Employed in preclinical research for developing and testing tolerogenic vaccines aimed at modulating autoimmune responses.
• Diagnostic Tool Development: Serves as a coating antigen or standard in ELISA and other immunoassays to detect and quantify anti-MBP antibodies in patient samples.
• Neuroscience Research: Used to investigate the role of specific MBP epitopes in myelin stability and the breakdown processes in demyelination.
• Pharmaceutical Screening: Applied in high-throughput screening platforms to identify potential therapeutic compounds that modulate the immune response to MBP.

Basic Information

Item	Detail
Product Name	(Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (Bovine)
CAS No.	98474-60-3
Molecular Formula	C76H126N24O22
Molecular Weight	Contact for details
Synonyms	MBP (68-84), Bovine; MBP Peptide (68-84), Des-Gly77,Des-His78-; Myelin Basic Protein Fragment 68-84 (Bovine), modified; Encephalitogenic Peptide (Bovine); Antigenic Peptide MBP68-84; Ac-Ala-Ser-Asp-Tyr-Lys-Ser-Leu-Gly-Arg-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH; Ac-ASDYKSLGRFSWGAGQR-OH
EINECS	Contact for details

Quality Control

Every batch of (Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (Bovine) is produced and analyzed under stringent quality management protocols to ensure identity, purity, and consistency for critical research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting research standards. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Complies with theoretical composition
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.