Description

Hydroxy Nefazodone Dihydrochloride is a high-purity pharmaceutical intermediate and reference standard. This compound is critical for research and development in neuropharmacology, particularly in the study of serotonin receptor modulation. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and academic research institutions engaged in the development and quality control of central nervous system (CNS) active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced neuropsychiatric drug candidates.
• Analytical Reference Standard: Used for method development, validation, and quality control (QC/QA) testing in pharmaceutical analysis.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research related to nefazodone and its analogs.
• Biochemical Research: Serves as a tool compound for in-vitro studies targeting 5-HT receptor systems.
• Impurity Standard: Critical for identifying and quantifying related substances in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Hydroxy Nefazodone Dihydrochloride
CAS No.	98159-83-2
Molecular Formula	C25H34Cl2N5O2
Molecular Weight	515.47 g/mol
Synonyms	2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one dihydrochloride; 1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-4-ethyl-4-(2-phenoxyethyl)-δ²-1,2,4-triazolin-5-one dihydrochloride; Hydroxynefazodone Dihydrochloride; Nefazodone Metabolite Hydroxy Triazoledione Dihydrochloride; CP-44873-1; OH-Nefazodone 2HCl
EINECS	Contact for details

Quality Control

Our Hydroxy Nefazodone Dihydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.