Description

Atriopeptin I is a specific, biologically active peptide fragment derived from the atrial natriuretic peptide (ANP) precursor. This compound is a critical research tool for studying cardiovascular physiology, renal function, and hormone signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cardiometabolic drug discovery and biochemical analysis.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of natriuretic peptide receptors (NPR-A, NPR-C) and their signaling cascades.
• Cardiovascular Pharmacology: Investigation of vasodilation, blood pressure regulation, and heart failure mechanisms.
• Renal Physiology Studies: Research into natriuresis, diuresis, and electrolyte balance in kidney function models.
• Enzyme Activity Assays: Serves as a substrate or inhibitor in studies of proteolytic enzymes like corin and neprilysin.
• Diagnostic Development: Potential use in the calibration and validation of immunoassays targeting ANP-related peptides.
• Signal Transduction Research: Elucidation of cyclic GMP (cGMP)-mediated pathways in various cell types.

Basic Information

Product Name	Atriopeptin I
CAS No.	98084-68-5
Molecular Formula	C106H170N34O31S2
Molecular Weight	2412.8 g/mol
Synonyms	Atrial Natriuretic Peptide (103-115); ANP (103-115); Atriopeptin-11; Cardionatrin I; rANP (103-115); H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Cys-OH (disulfide bridge: Cys4-Cys15); Atrial Natriuretic Factor (103-115); ANF (103-115)
EINECS	Contact for details

Quality Control

Our Atriopeptin I is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, assay results, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.