Description

(7R)-7-[[(R)-[[[(2-Furoyl)Amino]Carbonyl]Amino]Phenylacetyl]Amino]-3-[[(1-Methyl-1H-Tetrazol-5-Yl)Thio]Methyl]Cepham-3-Ene-4-Carboxylic Acid is a key advanced pharmaceutical intermediate in the synthesis of third-generation cephalosporin antibiotics. This compound is valued for its role in constructing the complex molecular framework required for broad-spectrum antibacterial activity. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of potent β-lactam antibiotics.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: As a critical building block in the chemical synthesis of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and optimization of new antibacterial agents with improved efficacy.
• Process Chemistry: Serves as a key intermediate in scaling up manufacturing processes for commercial antibiotic production.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.
• Antibacterial Mechanism Studies: Utilized in biochemical research to study the structure-activity relationships of β-lactam compounds.

Basic Information

Item	Details
Product Name	(7R)-7-[[(R)-[[[(2-Furoyl)Amino]Carbonyl]Amino]Phenylacetyl]Amino]-3-[[(1-Methyl-1H-Tetrazol-5-Yl)Thio]Methyl]Cepham-3-Ene-4-Carboxylic Acid
CAS No.	98048-76-1
Molecular Formula	C26H24N8O7S2
Molecular Weight	624.65 g/mol
Synonyms	7β-[(R)-2-[[(2-Furoylcarbamoyl)amino]-2-phenylacetamido]-3-[(1-methyl-1H-tetrazol-5-ylthio)methyl]-3-cephem-4-carboxylic Acid; Cefotetan Intermediate; Cefotetan Derivative; 7-ACA Derivative; 3-[(1-Methyl-1H-tetrazol-5-ylthio)methyl]cephem Intermediate; (6R,7R)-7-[[(R)-2-[[(Furan-2-carbonyl)carbamoyl]amino]-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for use in API synthesis. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.