Description

4-Oxoazetidine-2-Carboxylic Acid is a high-value, non-proteinogenic β-lactam amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its constrained azetidine ring structure makes it an essential precursor for developing novel pharmaceuticals and bioactive compounds. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for the synthesis of protease inhibitors, antibiotics, and other specialized active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of β-lactamase inhibitors and novel antibiotic candidates.
• Protease Inhibitor Development: Used as a core scaffold in the design and synthesis of inhibitors targeting various serine proteases.
• Peptidomimetics & Constrained Peptides: Incorporates conformational rigidity into peptide backbones for enhanced metabolic stability and binding affinity in drug discovery.
• Agrochemical Synthesis: Serves as a building block for creating novel active ingredients with specific biological activity.
• Biochemical Research: Utilized as a standard or reagent in enzymatic studies and metabolic pathway investigations.
• Fine Chemical Production: Intermediate for the manufacture of specialty chemicals, catalysts, and ligands used in asymmetric synthesis.

Basic Information

Product Name	4-Oxoazetidine-2-Carboxylic Acid
CAS No.	98019-65-9
Molecular Formula	C4H5NO3
Molecular Weight	115.09 g/mol
Synonyms	(2S)-4-Oxoazetidine-2-carboxylic acid; L-4-Oxoazetidine-2-carboxylic acid; 4-Oxo-2-azetidinecarboxylic acid; 3-Amino-2-oxetanone-4-carboxylic acid; Azetidine-2-carboxylic acid, 4-oxo-; (S)-4-Oxoazetidine-2-carboxylic acid; 2-Azetidinecarboxylic acid, 4-oxo-; NSC 163023
EINECS	Contact for details

Quality Control

Our 4-Oxoazetidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.