Description

Dibucaine-D9 Hydrochloride is a deuterated analog of the local anesthetic dibucaine, specifically labeled with nine deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical methods. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS quantification of dibucaine in biological matrices (plasma, serum, urine).
• Metabolite identification and pharmacokinetic (PK) studies in drug discovery and development.
• Bioanalytical method development and validation for regulatory submissions.
• Quality control and assurance in pharmaceutical manufacturing of dibucaine-containing products.
• Isotope dilution mass spectrometry for precise and accurate concentration measurements.
• Research into the mechanism of action and metabolic pathways of local anesthetics.

Basic Information

Product Name	Dibucaine-D9 Hydrochloride
CAS No.	98006-44-1
Molecular Formula	C20H20D9N3O2•HCl
Molecular Weight	391.98 g/mol (approx.)
Synonyms	2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide-d9 hydrochloride; Cinchocaine-d9 Hydrochloride; Sovcaine-d9 Hydrochloride; Percaine-d9 Hydrochloride; Dibucaine-d9 HCl; 4-Aminobenzoic Acid 2-(Diethylamino)ethyl Ester-d9 Hydrochloride (common misnomer); Nupercainal-d9 Hydrochloride
EINECS	Contact for details

Quality Control

Our Dibucaine-D9 Hydrochloride is manufactured under controlled conditions to ensure the highest isotopic and chemical purity. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (D9, min. 98 atom % D), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.