Description

1-(n-Carbobenzoxy-γ-Glutamyl)Indoline-2-Carboxylic Acid is a sophisticated, high-purity chemical building block designed for advanced pharmaceutical and peptide synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture in the development of novel therapeutic agents. It serves as a key intermediate for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate specific indoline and glutamyl motifs into peptide chains.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs targeting various disease pathways.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for the development and optimization of scalable, GMP-compliant manufacturing processes.
• Bioconjugation & Probe Development: Can be utilized for creating labeled peptides or conjugates for diagnostic and research applications.

Basic Information

Product Name	1-(n-Carbobenzoxy-γ-Glutamyl)Indoline-2-Carboxylic Acid
CAS No.	97975-31-0
Molecular Formula	C22H22N2O7
Molecular Weight	426.42 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-L-γ-glutamyl-2-indolinecarboxylic Acid; Z-γ-Glu(Indoline-2-COOH)-OH; Cbz-γ-Glu(2-Indolinecarboxylic Acid); 1-(N-Cbz-γ-Glutamyl)Indoline-2-Carboxylic Acid; N-Carbobenzoxy-γ-glutamylindoline-2-carboxylic Acid; (2S)-1-[(2S)-5-(Benzyloxy)-4-[(benzyloxy)carbonyl]amino]-5-oxopentanoyl]-2,3-dihydro-1H-indole-2-carboxylic Acid; Z-Glu(2-Indoline-COOH)-OH; 97975-31-0
EINECS	Contact for details

Quality Control

Our 1-(n-Carbobenzoxy-γ-Glutamyl)Indoline-2-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to stringent internal specifications and can provide material that aligns with the requirements of ICH Q3A/B guidelines for pharmaceutical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 2.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.