Description

1-(Difluoromethoxy)-2-Fluorobenzene is a specialized fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique difluoromethoxy and fluoro substituents make it a valuable precursor for introducing specific fluorine-containing motifs into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where its structural features can enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates requiring fluorinated aromatic ether structures.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where fluorine atoms are critical for efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic compounds used in electronic display technologies and organic light-emitting diodes.
• Specialty Polymer Modification: Employed to introduce fluorine into polymer backbones or side chains to alter properties like chemical resistance, thermal stability, and surface energy.
• Organic Synthesis & Catalysis Research: A valuable reagent in academic and industrial R&D for studying novel fluorination reactions and catalytic processes.
• Fluorinated Surfactant & Lubricant Development: Acts as an intermediate in the synthesis of specialty surfactants and high-performance lubricants with unique surface properties.

Basic Information

Product Name	1-(Difluoromethoxy)-2-Fluorobenzene
CAS No.	97963-49-0
Molecular Formula	C7H5F3O
Molecular Weight	162.11 g/mol
Synonyms	2-Fluoro-1-(difluoromethoxy)benzene; o-Fluorophenyl difluoromethyl ether; 1-Fluoro-2-(difluoromethoxy)benzene; Difluoromethoxy-2-fluorobenzene; (Difluoromethoxy)fluorobenzene; Benzene, 1-(difluoromethoxy)-2-fluoro-; 2-Fluorophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total
Density (at 20°C)	~1.3 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.