Description

(D-Phe7)-Bradykinin Acetate is a synthetic, biologically active peptide analog of the endogenous vasoactive nonapeptide bradykinin. This modified sequence, featuring a D-phenylalanine substitution at position 7, is designed to enhance metabolic stability and receptor selectivity for advanced research applications. It serves as a critical tool compound for pharmaceutical R&D, biochemical studies, and diagnostic development. Researchers in pharmacology, cardiovascular biology, and neuroscience utilize this high-purity peptide to investigate bradykinin receptor (B1/B2) signaling pathways and therapeutic potential.

Application

• Pharmacological Research: Used as a selective ligand for studying bradykinin receptor subtypes (B1 and B2) in vitro and in vivo.
• Drug Discovery & Development: Serves as a reference standard and lead compound for designing novel peptide-based therapeutics targeting inflammation, pain, and cardiovascular conditions.
• Biochemical Assays: Employed in enzyme inhibition studies, receptor binding assays, and signal transduction pathway analysis.
• Academic & Institutional Research: A key reagent for fundamental research in vascular biology, neurobiology, and inflammatory disease mechanisms.
• Diagnostic Kit Manufacturing: Can be utilized in the development of immunoassays and diagnostic tests for clinical research.
• Quality Control & Reference Standard: Acts as a certified reference material (CRM) for analytical method validation and quality assurance in peptide production.

Basic Information

Product Name	(D-Phe7)-Bradykinin Acetate
CAS No.	97825-00-8
Molecular Formula	C58H81N15O12 • (C2H4O2)x
Molecular Weight	~1180.4 g/mol (free base)
Synonyms	Bradykinin, D-Phenylalanine-7-; [D-Phe7]-Bradykinin acetate salt; H-Arg-Pro-Pro-Gly-Phe-Ser-D-Phe-Pro-Arg-OH acetate; Des-Arg9-[D-Phe7]-Bradykinin precursor; BK (1-9), D-Phe7-; B2 Receptor Ligand, D-Phe7 analog; Kallidin I analog; RPPGFSPFR (D-Phe7) acetate
EINECS	Contact for details

Quality Control

Our (D-Phe7)-Bradykinin Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) detailing purity, acetate content, residual solvents, and endotoxin levels where applicable, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Acetate Content (Ion Chromatography)	5 - 12%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.