Description

Lipopolysaccharide From Salmonella Minnesota R5 (Re) is a highly purified bacterial endotoxin derived from the rough mutant strain of Salmonella Minnesota. This product is critical for immunological research and quality control applications due to its standardized biological activity. It is primarily utilized by pharmaceutical, biotechnology, and academic research laboratories requiring a reliable and consistent source of endotoxin for challenge studies, pyrogen testing, and innate immune response research.

Application

• Limulus Amebocyte Lysate (LAL) Testing: Used as a standard or control in assays to detect and quantify bacterial endotoxins in pharmaceutical products, medical devices, and water for injection.
• Immunological Research: Serves as a potent agonist for Toll-like Receptor 4 (TLR4) to study innate immune signaling pathways, cytokine production, and inflammation models.
• Vaccine Adjuvant Development: Investigated for its immunostimulatory properties in the formulation and research of novel vaccine candidates.
• Cell Culture Stimulation: Used to activate macrophages, dendritic cells, and other immune cells in vitro to study cellular responses.
• Pyrogenicity Studies: Employed in research to understand fever response and develop testing protocols for parenteral drugs.
• Quality Control & Validation: Acts as a reference material for the validation of endotoxin detection methods and equipment in GMP/GLP environments.

Basic Information

Product Name	Lipopolysaccharide From Salmonella Minnesota R5 (Re)
CAS No.	97808-43-0
Molecular Formula	Contact for details
Molecular Weight	High molecular weight polymer
Synonyms	LPS (Salmonella minnesota R5); Endotoxin (Salmonella minnesota R5); Bacterial Lipopolysaccharide R5; S. minnesota R595 LPS; Lipopolysaccharide from Salmonella minnesota Re mutant; TLR4 Agonist (Salmonella); Monophosphoryl Lipid A precursor; Rough-form LPS
EINECS	Contact for details

Quality Control

Our Lipopolysaccharide From Salmonella Minnesota R5 (Re) is produced and tested under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot is characterized for key parameters including endotoxin activity units (EU/mg) and purity. Certificates of Analysis (COA) detailing specifications and test results are provided to support your research and quality systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Endotoxin Activity	≥ 1 x 10⁶ EU/mg (Typical)
Protein Content	< 1% (by weight)
Nucleic Acid Content	< 1% (by weight)
Solubility	Soluble in water or pyrogen-free buffer with sonication
Biological Activity	Activates TLR4 reporter cells (e.g., HEK-Blue™ hTLR4 cells)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.