Description

Hemoglobin F-Dammam is a specific variant of fetal hemoglobin (HbF) characterized by a point mutation, primarily used as a critical reference material and biochemical reagent in hematological research and diagnostics. This compound matters for its essential role in the study of hemoglobinopathies, particularly those affecting fetal hemoglobin expression and function. It is needed by research institutions, diagnostic laboratories, and pharmaceutical companies focused on developing therapies for sickle cell disease, β-thalassemia, and other blood disorders.

Application

• Biochemical Research Standard: Serves as a purified reference standard for comparative studies of hemoglobin structure, function, and oxygen-binding kinetics.
• Diagnostic Assay Development: Used in the development and calibration of diagnostic kits and assays for detecting and quantifying abnormal hemoglobin variants.
• Hematology Studies: Essential for in-vitro studies investigating the pathophysiology of hemoglobin disorders like sickle cell disease and thalassemias.
• Therapeutic Research: Employed in research aimed at modulating fetal hemoglobin expression as a therapeutic strategy for certain blood diseases.
• Quality Control Material: Acts as a control material in clinical laboratories to ensure the accuracy of hemoglobin electrophoresis and chromatography methods.
• Educational & Training Tool: Used in academic settings for teaching advanced concepts in molecular hematology and protein biochemistry.

Basic Information

Product Name	Hemoglobin F-Dammam
CAS No.	97708-56-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Hb F-Dammam; Hemoglobin F Dammam; Fetal Hemoglobin Dammam variant; HbF-Dammam; Hemoglobin F (Dammam); Dammam Hemoglobin F; α2γ2121 Glu→Lys; Hemoglobin F with 121(GH4)Glu→Lys substitution
EINECS	Contact for details

Quality Control

Our Hemoglobin F-Dammam is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analysis, including purity assessment by HPLC and confirmation of identity. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture. For short-term use, aliquoting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in appropriate aqueous buffers
Protein Content	Determined by UV-Vis spectroscopy
Endotoxin Level	< 1.0 EU/mg (where applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.