Description

L-Proline, 4-Hydroxy-2-Methyl-, trans- (9Ci) is a specialized, non-proteinogenic proline derivative characterized by its unique hydroxyl and methyl substitutions on the pyrrolidine ring. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a key chiral building block or intermediate for novel therapeutics. Its structural features make it valuable for applications in peptide mimetics, enzyme inhibitors, and other bioactive molecule synthesis, serving the needs of pharmaceutical R&D, biotechnology, and fine chemical synthesis sectors.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of complex drug candidates, including protease inhibitors and other targeted therapies.
• Peptide Mimetic Design: Used to introduce conformational constraints and enhance metabolic stability in the development of novel peptide-based drugs.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate biological pathways and mechanisms.
• Fine Chemical Synthesis: Acts as a versatile building block for the preparation of specialty chemicals with high stereochemical purity.
• Asymmetric Catalysis: May be utilized as a ligand or precursor in the development of chiral catalysts for stereoselective reactions.

Basic Information

Product Name	L-Proline, 4-Hydroxy-2-Methyl-, trans- (9Ci)
CAS No.	97673-81-9
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(2S,4R)-4-Hydroxy-2-methylpyrrolidine-2-carboxylic acid; trans-4-Hydroxy-2-methyl-L-proline; (2S,4R)-4-Hydroxy-2-methylproline; 4-Hydroxy-2-methyl-L-proline; L-4-Hydroxy-2-methylproline; 2-Methyl-4-hydroxy-L-proline; 97673-81-9
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-2-Methyl-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.